Athletes and bodybuilders use clenbuterol is mainly due to its thermogenic and anti-catabolic effects.
Clenbuterol (often simply called “maple”) – is not a steroid, is a sympathomimetic and central nervous system stimulant, a specific agonist which stimulates beta-2 adrenoceptors. In some countries it is used in medicine as bronholiticheskigo for the treatment of asthma because of the long half-life. However, in the US and the UK it is not allowed to use.
Athletes and bodybuilders use clenbuterol is mainly due to its thermogenic and anti-catabolic effects. Effect of the drug is that it significantly increases the core body temperature. This increases the calorie consumption. It is believed that the increase in body temperature by 1 ° volume increases calorie burning by 5%. Animal studies suggest that clenbuterol has an anabolic properties. These drug effects are mild in humans, probably because of the small numbers of beta-3 receptors, increases the production and insulin sensitivity.
The drug is dosed micrograms. The most common form is a tablet, although there are other forms – solutions, nasal sprays and injections. Note that although the drug is dosed micrograms, many manufacturers indicate the amount of active ingredient in milligrams thus on a tablet weighing 20 g will be given 0.02 mg.
Side effects and possible effects of Clenbuterol
The degree of side effects depends on the dose of clenbuterol, while taking the drug say that the majority of side effects diminish with prolonged administration. It is recommended to be used with caution Clenbuterol in conjunction with other adrenoceptor agonists as side effects may be intensified. For this reason it is not recommended to take with maple ephedrine, or a combination of ephedrine-caffeine-aspirin.
The most common side effects of Clenbuterol include:
- Muscle tremors (especially hand tremor);
- Muscle cramps;
- Increased sweating;
- Increased appetite;
- Hypertension (high blood pressure);
- Possible cardiac hypertrophy as maple affects the smooth muscle fibers of the heart and muscle tissues;
- In animal studies, phenomena were observed tissue necrosis of cardiac muscle.
Considering the listed side effects of the drug, should not take stimulants like Clenbuterol, those with impaired cardiac function or hypertension. Taking the drug with caution should be those who are already taking these drugs for treatment. In addition, there is not enough reliable information on the cardiac effects of high doses of the drug in humans.
It is well known that the use of clenbuterol inhibits beta-2 receptors. This is due to the stimulating effect of the preparation. So take maple for long periods without interruption inappropriate. It is believed that the alternation of two days of drug administration with a two days break keeps the susceptibility of the receptors. However, clenbuterol has a relatively long half-life, and the drug continues to operate even during the breaks. A more practical two-week course will be taking the drug with a two-week break. Maximum plasma drug concentration achieved after 2 to 3 hours after oral administration, and half-life of 34 hours. (Research Zimmer, 1976).
A gradual increase in the dose recommended to prevent the possible severe side effects. It is usually recommended to start a course to receive one tablet (20 mg) on the first day, increasing to one tablet daily. Assuming normal tolerability, the seventh day dose of 140 mg (7 tablets), and that amount should be taken throughout the second week of the course. Exceed this dose does not make sense, because it will cause a glut receptors. The gradual reduction of the dose is also not necessary.
In the course of the next cycle, the 5th and 6th week, so it is not necessary to gradually increase the dose, since one tablet is now known as you as your body carries the drug. For example, if the first round was finished on seven tablets a day, then the next, you can start with a 4 – 5 tablets, and gradually increase to seven. This is followed again restrict the 7 th or 8 tablets per day.
During the two-week break and if you want to take a mixture of ephedrine-caffeine-aspirin (ECA). ECA will not cause such inhibition and receptor desensitization as Maple. In comparison with the maple, from ephedrine short half-life, so the buds have time to recover from stimulation by adrenaline and noradrenaline. Strength of ephedrine and less than Maple because it is not a specific agonist. It is believed that ephedrine accelerates the conversion of endogenous and exogenous thyroxine to triiodothyronine through the activation of the enzyme monodeiodinase regulating this process. This important property of ephedrine as Maple slows the conversion of thyroxine to triiodothyronine. It is worth noting that some bodybuilders take drugs triiodothyronine simultaneously with Clenbuterol / ECA courses “drying” of muscle (of course, together with certain anabolic / androgenic steroids) to maintain normal levels of triiodothyronine in blood. The duration of the courses Maple / ECA is normally limited by 12 weeks, and sometimes less time.
Women tend to take smaller doses than men. Max at the reception is 80 – 120 g (4 – 6 tablets).
In addition to the fat burning effect of clenbuterol, it is often used as an anti-catabolic in drug after courses of steroids to maintain the gain muscle mass. In this case the dose is 40 micrograms per day.
Because of the long half-life of Clenbuterol is not necessary to divide the daily dose into several times. Most people take the entire dose in the morning, though some are taking medication before bed in order not to suffer from side effects in the waking state.
It is believed that the division of the daily dose into several times a little help ease the side effects. The most appropriate regime for the administration of the drug itself can pick up watching the reactions of the organism.
Muscle cramps – the most common side effect of clenbuterol. They probably occur because the depletion of taurine in the liver in combination with deficient electrolytes sodium and potassium, and inadequate hydration. Taurine helps to strengthen cell membranes and prevents the excitement of the nervous system. Some studies show that getting taurine as an additive reduces the painful muscle spasms. Japanese scientists have found that the longer the experimental rats were exposed to physical stress, the more taurine lose their muscles. (Study Mattsuzaki 2002)
Symptoms of muscle cramps can be facilitated by such means:
- Eating fruits, especially bananas;
- Ensuring adequate hydration;
- Additional supplementation with taurine, 3 – 5 grams per day;
- Potassium supplements, 200 – 400 mg daily at bedtime on an empty stomach.
Ketotifen – is an antihistamine used in medicine for the treatment of asthma and allergies. It produces a sedative and calming effect on the nervous system. Its effect is to reduce histamine release that accompanies allergic reactions. Ketotifen blocks the action of histamine receptors and reduces response of the nervous system to allergic reactions.
Histamine – a biogenic compound body, which under certain conditions causes hypersensitivity reactions, i.e. allergies. Allergic reactions can manifest inflammation of the skin, respiratory tract, or body tissues, rashes, itching of the skin, eyes or mucous membranes, nasal congestion or a narrowing of the airways.
Bodybuilders are showing interest in the drug, since it prevents the inhibition of beta receptors, which are affected by Maple. Ketotifen clears these receptors, preventing them from oppression, even during the strengthening of the Clenbuterol. This means that you can take clenbuterol indefinitely without interruption to restore the sensitivity of receptors. The daily intake of 2 – 3 mg ketotifen can restore susceptibility of even heavily oppressed receptors for one week. Furthermore, in this case there is no need to increase the dose of clenbuterol to achieve the same results. It can take 30-40% less maple, and this dose will be as effective.
Studies that establish the optimal dosage ketotifen, has been conducted, but most consider taking a dose of 3 to 4 mg of the ideal. It can be divided into portions, or receive at one time. Higher doses may cause drowsiness and increased appetite (sometimes augmented degree).